Epidemiology and Infection, fixed by medium of The Journal of Hygiene in Hope-Simpson's instance, just freshly published our weekly. The editor, Professor Norman Noah, know Dr. Hope-Simpson and help tremendously beside the paper. In the paper, we detailed our proposition that vitamin D be Hope-Simpson's extensive forgotten "seasonal stimulus." We proposed that annual fluctuations in vitamin D level recapitulate the seasonality of respiratory tract pollution. The interrupted seasonal fluctuations in 25-hydroxy-vitamin D levels, which effect permanent and inescapable wintertime vitamin D a reduced amount of, dispose human populations to influenza epidemic. We magnification up the possible event that influenza is a symptom of vitamin D deficiency in duplicate approach that an unknowable practice of pneumonia (pneumocystis carinii) is a symptom of AIDS. That is, we theorize that George Bernard Shaw be rightly when he said, "the peculiar microbe of a bug can be a symptom instead of a cause." In the paper, we advise that vitamin D explain the behind 14 observations: 1. Why the virus predictably travel off in the months following the winter solstice, when vitamin D levels be at their lowest, 2. Why it go missing in the months following the summer solstice, 3. Why influenza is more established in the tropics during the raining cats and dogs season, 4. Why the unpleasantly cold and rainy weather associated with El Nino Southern Oscillation (ENSO), which drive individuals indoors and shame vitamin D blood levels, is associated with influenza, 5. Why the rate of reverberation of influenza is inversely correlated with outdoor temperature, 6. Why be in a strop given away to rays are less important number expected to rod colds, 7. Why cod liver grease (which contain vitamin D) downsize the incidence of viral respiratory infection, 8. Why Russian scientists found that vitamin D-producing UVB kerosene lamp reduced colds and flu in schoolchildren and factory human resources, 9. Why Russian scientists found that volunteers, purposely festering with a helpless flu virus - slit in the summer and latter again in the winter - appearance momentously not like clinical course in the different season, 10. Why the elderly who occupy country with illustrious vitamin D ingestion, in the vein of Norway, are less likely to depart this heartiness in the winter, 11. Why children with vitamin D deficiency and rickets suffer from seasoned respiratory infections, 12. Why an observant physician (Rehman), who hand over high dose of vitamin D to children who be interminably queasy from colds and the flu, found the treat children were without hesitation on top of the loose from infection, 13. Why the elderly are for that object markedly more likely to die from heart attack in the winter truthfully than in the summer, 14. Why African Americans, with their at a low level vitamin D blood levels, are more likely to die from influenza and pneumonia than Whites are.
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